abstract：:The characteristics and impact of pain were evaluated in a prospective cross-sectional survey of 438 ambulatory AIDS patients recruited from health care facilities in New York City. More than 60% of the patients reported 'frequent or persistent pain' during the 2 wks preceding the study. Patients with pain reported an...

journal_title：Pain

authors： Breitbart W,McDonald MV,Rosenfeld B,Passik SD,Hewitt D,Thaler H,Portenoy RK

更新日期：1996-12-01 00:00:00

abstract：:A psychophysical investigation was carried out to examine whether heat hyperalgesia exists within the secondary mechanical hyperalgesia zone surrounding a capsaicin injection site on hairy skin. A non-contact laser stimulator was used to deliver temperature controlled stimuli to sites within and outside the zone of me...

journal_title：Pain

authors： Ali Z,Meyer RA,Campbell JN

更新日期：1996-12-01 00:00:00

abstract：:Manipulative therapy is frequently used in the management of musculoskeletal pain. A frequently reported clinical feature of this treatment is the immediacy with which it appears to initiate improvement in pain and function. A randomised, double blind, placebo controlled, repeated measures design was employed to study...

journal_title：Pain

authors： Vicenzino B,Collins D,Wright A

更新日期：1996-11-01 00:00:00

abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...

journal_title：Pain

authors： Lang E,Hord HA,Denson D

更新日期：1996-11-01 00:00:00

abstract：:We investigated the question of how cultural and linguistic backgrounds affect relationships among ratings (reported by patients with metastatic cancer) of pain's interference with such functions as activity, mood, and sleep. Multidimensional scaling (MDS) was used to analyze ratings of pain interference from a sample...

journal_title：Pain

authors： Cleeland CS,Nakamura Y,Mendoza TR,Edwards KR,Douglas J,Serlin RC

更新日期：1996-10-01 00:00:00

abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...

journal_title：Pain

authors： Mao J,Price DD,Caruso FS,Mayer DJ

更新日期：1996-10-01 00:00:00

abstract：:Ten patients who suffered from severe cancer-related pain participated in a randomised, double-blind and cross-over study to compare the effectiveness and acceptability of epidural and subcutaneous administration of morphine. The patients titrated themselves pain-free in 48 h using a patient controlled analgesia syste...

journal_title：Pain

authors： Kalso E,Heiskanen T,Rantio M,Rosenberg PH,Vainio A

更新日期：1996-10-01 00:00:00

abstract：:In the present study, Brandtstädter's (1992) distinction between assimilation and accommodation as two fundamental means of coping is applied to the field of chronic pain. Assimilative coping involves active attempts (e.g. instrumental activities, self-corrective actions, compensatory measures) to alter unsatisfactory...

journal_title：Pain

authors： Schmitz U,Saile H,Nilges P

更新日期：1996-09-01 00:00:00

abstract：:Noradrenaline increases thermal hyperalgesia in skin previously sensitized by capsaicin. The aim of the present study was to determine whether a vasoconstrictor ischaemic effect of noradrenaline increases thermal hyperalgesia. Heat pain thresholds were measured in the capsaicin-treated and untreated skin on the forear...

journal_title：Pain

authors： Drummond PD

更新日期：1996-09-01 00:00:00

abstract：:Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...

journal_title：Pain

authors： Kornguth PJ,Keefe FJ,Conaway MR

更新日期：1996-08-01 00:00:00

abstract：:The present study describes a new test of tonic pain to be used as an animal model of persistent pain. First, pain responses and edema produced by subcutaneous injection of increasing doses of honey bee venom into the hind paw of the rat were quantified. Second, the effect of morphine and aspirin on the pain responses...

journal_title：Pain

authors： Lariviere WR,Melzack R

更新日期：1996-08-01 00:00:00

abstract：:Treatment of adult rats with a single dose of nerve growth factor (NGF, 1 mg/kg, i.p.) results in a prolonged hypersensitivity to noxious thermal stimulation which becomes noticeable within 30 min of administration and lasts for several days. A significant mechanical hyperalgesia develops within 7 h following injectio...

journal_title：Pain

authors： Rueff A,Dawson AJ,Mendell LM

更新日期：1996-08-01 00:00:00

abstract：:Pain evoked potentials (EPs) have been used in the last two decades as means of obtaining objective measures of pain, in clinical and experimental setups. The possibility that the pain EP wave contains elements of the endogenous P300 potential rather than being a neurophysiological correlate of pain has been raised by...

journal_title：Pain

authors： Zaslansky R,Sprecher E,Tenke EC,Hemli AJ,Yarnitsky D

更新日期：1996-07-01 00:00:00

abstract：:Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...

journal_title：Pain

authors： Quijada-Carrera J,Valenzuela-Castaño A,Povedano-Gómez J,Fernández-Rodriguez A,Hernánz-Mediano W,Gutierrez-Rubio A,de la Iglesia-Salgado JL,García-López A

更新日期：1996-05-01 00:00:00

abstract：:This article reports on a study that examines the influence of task-related factors on nurses' pain assessments and decision regarding interventions. In an experimental design pediatric nurses (n = 202), were exposed to different cases, each case being a combination of a vignette and a videotape. For every case subjec...

journal_title：Pain

authors： Hamers JPH,Abu-Saad HH,van den Hout MA,Halfens RJG,Kester ADM

更新日期：1996-04-01 00:00:00

abstract：:Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...

journal_title：Pain

authors： Veldman PHJM,Goris JAR

更新日期：1996-03-01 00:00:00

abstract：:Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...

journal_title：Pain

authors： Spinella M,Cooper ML,Bodnar RJ

更新日期：1996-03-01 00:00:00

abstract：:Experimental muscle pain was elicited by bolus injection of 0.15 ml of 5% hypertonic saline into the human masseter muscle. The sensory experience was described using 10-cm visual analogue scales (VAS) and the McGill Pain Questionnaires (MPQ) on 10 subjects. Effects of pain on deliberately unilateral mastication were ...

journal_title：Pain

authors： Svensson P,Arendt-Nielsen L,Houe L

更新日期：1996-02-01 00:00:00

abstract：:Nerve growth factor (NGF) is known to produce hyperalgesia as well as to stimulate synthesis of neuropeptides in dorsal root ganglia (DRG). In the present study, we wanted to determine the effects of local NGF administration and assess to which extent mast cell-dependent factors are mediating NGF responses. Rats recei...

journal_title：Pain

authors： Amann R,Schuligoi R,Herzeg G,Donnerer J

更新日期：1996-02-01 00:00:00

abstract：:Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blin...

journal_title：Pain

authors： Lander J,Hodgins M,Nazarali S,McTavish J,Ouellette J,Friesen E

更新日期：1996-01-01 00:00:00

abstract：:Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of...

journal_title：Pain

authors： Dawson-Basoa ME,Gintzler AR

更新日期：1996-01-01 00:00:00

abstract：:The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

journal_title：Pain

authors： Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

更新日期：1995-12-01 00:00:00

abstract：:We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain. The hypothalamic-pituitary-adrenal (HPA) axis is known to respond to stressful stimuli, including pain. To examine whether the blockade of tolerance by pain is related to HPA activity, ...

journal_title：Pain

authors： Vaccarino AL,Couret LC Jr

更新日期：1995-12-01 00:00:00

abstract：:The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were p...

journal_title：Pain

authors： Schwartz G,Lund JP

更新日期：1995-11-01 00:00:00

abstract：:We describe audible and ultrasonic vocalization elicited in rats by a short electrical pulse applied to the tail. Three types of vocal emissions were recorded: (1) 'peep', characterized by a repartition of energy over a wide range (0-50 kHz) of frequencies without any clear structure; (2) 'chatters', characterized by ...

journal_title：Pain

authors： Jourdan D,Ardid D,Chapuy E,Eschalier A,Le Bars D

更新日期：1995-11-01 00:00:00

abstract：:Previous evidence suggests that, in adult animals, nerve growth factor (NGF) can induce hyperalgesia, and may be an endogenous mediator in some persistent pain states. Here we have studied the effects of single intradermal injections of 50-500 ng of human recombinant NGF into the plantar skin of adult rat hindpaws. We...

journal_title：Pain

authors： Andreev NY,Dimitrieva N,Koltzenburg M,McMahon SB

更新日期：1995-10-01 00:00:00

abstract：:Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...

journal_title：Pain

authors： Sugimoto T,Yoshida A,Nishijima K,Ichikawa H

更新日期：1995-10-01 00:00:00

abstract：:The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...

journal_title：Pain

authors： Abbott FV,Guy ER

更新日期：1995-09-01 00:00:00

abstract：:Compared with other European countries, French laws and restrictions concerning the use of opioids are of medium severity only. Still, together with Germany, Belgium and Spain, France belongs to the group of countries with a low national consumption of morphine, calculated by the International Narcotics Control Board ...

journal_title：Pain

authors： Vainio A

更新日期：1995-08-01 00:00:00

abstract：:There is evidence that serotonin may be implicated in the pathophysiology of myofascial pain (MFP). Because of this, we used oral sumatriptan (Imitrex, Glaxo), a peripherally acting agonist of 5-HT1D receptors, in a double-blind, randomized, placebo-controlled double crossover pilot study of 7 patients with episodic M...

journal_title：Pain

authors： Dao TTT,Lund JP,Rémillard G,Lavigne GJ

更新日期：1995-08-01 00:00:00

abstract：:Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now availabl...

journal_title：Pain

authors： Stubhaug A,Grimstad J,Breivik H

更新日期：1995-07-01 00:00:00

abstract：:To assess the efficacy of 4% topical lidocaine in spheno-palatine blocks, a randomized controlled trial was carried out on patients with chronic muscle pain syndromes. Sixty-one patients (42 with fibromyalgia (FM) and 19 with myofascial pain syndrome (MPS)) completed the trial. Outcome measures included pain intensity...

journal_title：Pain

authors： Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

更新日期：1995-07-01 00:00:00

abstract：:Twenty-six patients with severe pain associated with cancer were entered into a study where they were required to take morphine mixture for 7 days. Prior to this, their morphine dose had been optimised to provide the most favourable balance between pain relief and side effects. After 6 days of taking their optimised m...

journal_title：Pain

authors： Gourlay GK,Plummer JL,Cherry DA

更新日期：1995-06-01 00:00:00

abstract：:In a rat model of artificial ureteral calculosis, the aim of the study was to characterize the behavioural manifestations of direct visceral pain and to evaluate the relationship between number, duration and complexity of the visceral episodes and the extent of referred lumbar muscular hyperalgesia. As evidenced by no...

journal_title：Pain

authors： Giamberardino MA,Valente R,de Bigontina P,Vecchiet L

更新日期：1995-06-01 00:00:00

abstract：:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...

journal_title：Pain

authors： Sawynok J,Reid AR,Doak GJ

更新日期：1995-05-01 00:00:00

abstract：:This study evaluated the pre-emptive analgesic effect of intravenous (i.v.) ketorolac (KET) for total hip replacement (THR). Sixty patients who underwent surgery for THR under general anesthesia were randomly allocated to 3 groups. Two i.v. injections were administered: one before induction and one after surgery. The ...

journal_title：Pain

authors： Fletcher D,Zetlaoui P,Monin S,Bombart M,Samii K

更新日期：1995-05-01 00:00:00

abstract：:Postmastectomy pain (PMP), a distinctive postsurgical neuropathic pain syndrome, has been thought to be consequence of 4-6% of surgical procedures for cancer of the breast, but remains understudied and poorly documented. In this cross-sectional descriptive study, a convenience sample of 95 women who had undergone brea...

journal_title：Pain

authors： Stevens PE,Dibble SL,Miaskowski C

更新日期：1995-04-01 00:00:00

abstract：:In this review, the effectiveness of behavioral and pharmacological treatments for pediatric migraine was quantitatively summarized following the meta-analytic approach outlined by Hedges and Olkin (1985). A first meta-analysis based on treatment outcome within treatment conditions revealed that thermal biofeedback an...

journal_title：Pain

authors： Hermann C,Kim M,Blanchard EB

更新日期：1995-03-01 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a pain syndrome that is characterised by autonomic, motor and sensory disturbances. The syndrome has often been associated with sympathetic dysfunction. Therefore, we investigated whether there are disturbances in the sympathetic function of skin microcirculation in the various cl...

journal_title：Pain

authors： Kurvers HA,Jacobs MJ,Beuk RJ,Van den Wildenberg FA,Kitslaar PJ,Slaaf DW,Reneman RS

更新日期：1995-03-01 00:00:00

abstract：:A previous study of this laboratory showed that an acute myositis (which is associated with increased activity in slowly conducting muscle afferent fibres) is followed by marked excitability changes in the dorsal horn within a few hours. The present work addresses the question as to how the responsiveness of dorsal ho...

journal_title：Pain

authors： Hoheisel U,Beylich G,Mense S

更新日期：1995-02-01 00:00:00